Abstract Background There is increasing interest in enhancing the response of the PARP inhibitor olaparib, which is currently approved for pancreatic ductal adenocarcinoma (PDAC) patients with defects in DNA damage repair associated with germline BRCA1/2 mutations.Moreover, agents that can mimic these defects in the absence of germline BRCA1/2 muta
Adenostemma lavenia is a Mattress Protector perennial medical herb in the family Asteraceae.Here, we sequenced and analyzed the complete chloroplast genome of A.lavenia.The complete chloroplast genome size is 150,063 bp with a GC content of 37.63%.The A.lavenia chloroplast genome is a typical quadripartite structure, including a large single-copy r
Floods are the leading cause of hydrometeorological disasters in East Africa.Regardless of where, when, and how the event has happened, floods affect social security as Butter Dishes well as environmental damages.Understanding floods dynamics, their impacts, and management is thus critical, especially in climate risk assessment.In the present study
The human steroid 21-hydroxylase gene (CYP21A2) participates in cortisol and aldosterone biosynthesis, and resides together with its paralogous (duplicated) pseudogene in a multiallelic copy number variation (CNV), called RCCX CNV.Concerted evolution caused by non-allelic gene conversion has been described in great ape CYP21 genes, and the same con
Cryogenic LN2 fracturing is one of the environmentally friendly waterless fracturing technologies that promote the fracture complexity of shale gas reservoir.The water-ice phase transition under freezing condition causes frost heave in saturated shale.The effect of moisture in shale should be taken into account during cryogenic damage process.There